Hulk Stack (CJC-1295 with DAC & Ipamorelin) | 20mg

Hulk Stack (CJC-1295 with DAC & Ipamorelin) is a two-component research blend supplied in a single vial at 20mg, pairing CJC-1295 with DAC — a 30-residue analog of growth-hormone-releasing hormone carrying a Drug Affinity Complex — with Ipamorelin, a five-residue selective agonist of the growth-hormone-secretagogue receptor.

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The two molecules, side by side

The reason this pairing is studied as a pair is structural, not commercial: the two peptides are chemically unrelated and are characterized against two different receptor families. One is a class B secretin-family GPCR ligand; the other is a small, heavily modified pentapeptide built against a class A GPCR. Almost nothing about their handling, analysis or stability profile is shared.

The four backbone substitutions in CJC-1295 are what distinguish it from native GRF(1-29), and they do different jobs: D-Ala² closes the DPP-4 cleavage site, Gln⁸ removes an asparagine deamidation site, Ala¹⁵ is a potency and stability substitution, and Leu²⁷ removes an oxidation-prone methionine. The DAC is a separate, appended chemistry. Ipamorelin's unnatural residues are what make it a difficult synthesis and an easy compound to get subtly wrong — D-2-naphthylalanine and Aib are expensive building blocks, and epimerization at the D-residues and truncation at the hindered couplings are the impurity classes an analytical method for this component has to be able to resolve.

The DAC group is the part that drives your analytics

The Drug Affinity Complex is a maleimide, appended as a maleimidopropionyl group on the Lys³⁰ side chain. Maleimides are thiol-reactive: the designed reaction is a Michael addition across the ring double bond to a free sulfhydryl, forming a covalent thioether. That conjugation chemistry is the reason the group is there, so the buyer's question is whether the reactive handle is still intact in the vial.

The complication is that maleimides are hydrolytically labile. Ring opening to the maleamic acid adds roughly 18 Da and destroys the thiol-reactive handle without changing the peptide's appearance at all. Rate of ring opening rises with pH and with time in aqueous solution.

That single fact should shape how you read a certificate for this blend. A mass spectrum that resolves the intact species from a +18 Da shoulder is worth more than a purity percentage on its own, and it is a fair question to put to any supplier. It is also why format is a live analytical question for this blend rather than a matter of preference.

What a certificate for a blend has to prove

A blend is not one product with one number. Single-analyte documentation — one chromatogram, one "99.1%" line — cannot characterize a two-peptide vial. Ask for, or check for:

• Two resolved identity peaks. With a ≈2,935 Da mass gap and very different hydrophobicity, RP-HPLC and ESI-MS separate these two trivially. There is no technical excuse for a merged result.
• Per-component purity, each expressed against its own peak area, plus named impurities where they are quantified.
• Mass confirmation for both, ideally deconvoluted, showing the intact CJC-1295 with DAC species and the ipamorelin monoisotopic cluster.
• Content and ratio. The listing's 20mg figure should be read carefully — establish whether it describes total peptide content or per-component content, and whether net peptide content is corrected for counterion and water.
• Counterion and water. Synthesis peptides are commonly isolated as TFA or acetate salts. Residual TFA is cytotoxic in some in-vitro systems at levels that are otherwise unremarkable, so if your assay is cell-based, the salt form is a real experimental variable. Karl Fischer water content closes the mass balance.
• Lot traceability. The lot on the certificate must match the lot on the vial. A certificate for a different batch is a marketing document.

Our documentation library is at /coa.

Format: solution versus lyophilized powder

This is the genuine fork in the road for a US buyer, and both formats are supplied for blends of this type. Check the format stated on this listing before you order — do not assume either. The trade-offs are real in both directions.

Neither column is the safe default. The powder trades a preparation step against better shelf chemistry; the solution trades shelf chemistry against removing that step. Which trade suits you depends on your storage capability and on how the vial will be sampled — so read the format on the listing and match it to the bench.

Storage and handling

Keep sealed vials cold and dark; peptides with aromatic and imidazole side chains are photosensitive. Thermal cycling of any kind is a bigger practical threat to a blend than absolute storage temperature, because the two components do not degrade at the same rate — a cycled vial can drift in ratio while still looking clean by eye. Whatever format arrives, work in single-use portions for anything longitudinal. At low working concentrations, expect adsorptive loss to glass and untreated polypropylene, which is a common and under-diagnosed source of apparent potency loss in comparative work.

Origin and testing

This material is synthesized in the UK and verified in US laboratories. Beyond that, verification is your own responsibility as the buyer: retain the certificate against the lot you actually received, and record the receipt condition of the shipment — for any cold-sensitive format, the transit record is part of the data.

Published literature

Both compound classes are the subject of an ongoing body of in-vitro and animal laboratory research under examination, covering receptor binding, selectivity and analytical characterization. Nothing on this page draws conclusions from it.

For anyone operating under anti-doping rules: growth hormone secretagogues, including GHRH analogs and GHS-R agonists, appear on the WADA Prohibited List under class S2.

Related research blends

Other multi-component vials in the catalogue, each with a different component set and its own analytical considerations: Glow Stack, KLOW Stack, Wolverine Stack.